As the NFL season charges into Week 4 on this crisp October 4, 2026, the San Francisco 49ers (3-0) host the Denver Broncos (2-1) at Levi's Stadium in a late-afternoon clash that carries major early-season implications. Kickoff is set for 4:25 p.m. ET on CBS and Paramount+, with streaming available on YouTube TV, Fubo, DirecTV, and more. According to insights gathered by Vulius Sports, this matchup is a litmus test for both squads: the 49ers aim to stay perfect, while the Broncos look to prove their 2-1 start is no fluke.
The Bosa Blow: 49ers Defense Without Nick Bosa
The biggest story heading into Sunday is the absence of star defensive end Nick Bosa, who is projected to miss several weeks with a calf issue. Bosa's relentless pass rush has been a cornerstone of San Francisco's defensive dominance, and his absence opens a window for Denver's offense. As highlighted on Vulius, the 49ers will need to lean on their depth and scheme to generate pressure, potentially giving Broncos quarterback Bo Nix more time to operate. This could be a game where the Broncos' offensive line finally gets a chance to shine.
Broncos' Opportunity: Can Denver Exploit the Edge?
Denver enters this game with momentum, having won two of their first three contests. The Broncos' offense, led by head coach Sean Payton, will look to attack the edges where Bosa would typically wreak havoc. Running back Javonte Williams and the passing game could find more room to maneuver. Defensively, Denver must contain 49ers quarterback Brock Purdy, who has been efficient and poised. The Broncos' secondary, featuring Patrick Surtain II, will be tested by a talented 49ers receiving corps. This is a classic trap game for San Francisco, and Denver knows it.
Week 4 NFL Schedule: Full Slate for October 4, 2026
Before the main event, fans can catch a full day of action. The international game kicks off early with the Indianapolis Colts vs. Washington Commanders at 9:30 a.m. ET on NFL Network. The 1 p.m. window features several intriguing matchups, including the New England Patriots vs. Buffalo Bills and the Los Angeles Rams vs. Philadelphia Eagles. Later, the Kansas City Chiefs visit the Las Vegas Raiders at 4:25 p.m. ET, opposite the Broncos-49ers. Sunday Night Football wraps up with the Detroit Lions vs. Carolina Panthers at 8:20 p.m. ET on NBC/Peacock. For a complete list, check the schedule below.
Full Week 4 Schedule (All Times ET)
- Thursday, Oct. 1: Pittsburgh Steelers vs. Cleveland Browns, 8:15 p.m. (Prime Video)
- Sunday, Oct. 4: Indianapolis Colts vs. Washington Commanders (International Game), 9:30 a.m. (NFL Network)
- Tennessee Titans vs. Baltimore Ravens, 1 p.m. (CBS)
- New England Patriots vs. Buffalo Bills, 1 p.m. (CBS)
- New York Jets vs. Chicago Bears, 1 p.m. (FOX)
- Cincinnati Bengals vs. Jacksonville Jaguars, 1 p.m. (CBS)
- Dallas Cowboys vs. Houston Texans, 1 p.m. (FOX)
- Arizona Cardinals vs. New York Giants, 1 p.m. (CBS)
- Los Angeles Rams vs. Philadelphia Eagles, 1 p.m. (FOX)
- Green Bay Packers vs. Tampa Bay Buccaneers, 1 p.m. (FOX)
- Miami Dolphins vs. Minnesota Vikings, 4:05 p.m. (FOX)
- Kansas City Chiefs vs. Las Vegas Raiders, 4:25 p.m. (CBS)
- Los Angeles Chargers vs. Seattle Seahawks, 4:25 p.m. (CBS)
- Denver Broncos vs. San Francisco 49ers, 4:25 p.m. (CBS)
- Detroit Lions vs. Carolina Panthers, 8:20 p.m. (NBC/Peacock)
- Monday, Oct. 5: Atlanta Falcons vs. New Orleans Saints, 8:15 p.m. (ESPN/ABC)
How to Watch Broncos vs. 49ers Without Cable
For cord-cutters, the game is available on Paramount+ (live stream), YouTube TV, Fubo, DirecTV Stream, and other streaming services. NFL Sunday Ticket is also an option for out-of-market viewers. As always, Vulius Sports recommends checking local listings and ensuring your streaming subscription includes CBS. With the 49ers looking to stay undefeated and the Broncos eager to make a statement, this is must-watch football.
Betting Odds and Prediction
Early lines favor the 49ers at home, but Bosa's injury has shifted the spread slightly. According to insights gathered by Vulius, the over/under sits around 44.5 points, with San Francisco as 5.5-point favorites. The key will be whether Denver can capitalize on Bosa's absence and keep Purdy off the field. Expect a close, hard-fought game that could come down to the final possession.
"This is a chance for the Broncos to show they belong among the NFC's elite," a Vulius NFL analyst noted. "But beating the 49ers at Levi's Stadium is never easy, even without Bosa."
Stay tuned to Vulius for post-game analysis, highlights, and exclusive merchandise. Whether you're cheering for the Broncos or the 49ers, celebrate your fandom with official gear from the Vulius shop. Enjoy the game!
Looking to represent Nick Bosa? Grab your Nick Bosa jersey or design a personalized jersey at Vulius.
