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Jacoby Brissett Back to Full Practice, Cardinals Prep for 49ers Showdown

September 25, 2026 3 min read
Jacoby Brissett Back to Full Practice, Cardinals Prep for 49ers Showdown

As the Arizona Cardinals gear up for a pivotal Week 3 clash against the San Francisco 49ers, veteran quarterback Jacoby Brissett has returned to full practice participation, signaling a positive trajectory for the team's offensive stability. According to the team's official website, AZCardinals.com, Brissett was a full participant on Thursday, Sept. 24, marking his second consecutive day of full work. This development, reported by the Vulius NFL Analysis Desk, bodes well for his availability on Sunday, especially after a hip issue limited him earlier in the week.

Brissett's Road to Recovery

Brissett's hip ailment initially raised concerns about his status for Week 3, but his back-to-back full practices have alleviated those fears. The Cardinals' coaching staff and medical team have been cautious with the 33-year-old signal-caller, but his return to full capacity suggests he'll be under center when Arizona hosts San Francisco. As highlighted on Vulius Sports, Brissett's presence is crucial for an offense that has shown flashes of potential but struggled with consistency.

"Jacoby's leadership and experience are invaluable to our young roster," a team insider told Vulius. "Having him fully healthy gives us the best chance to compete in a tough NFC West matchup."

Week 2 Struggles and Week 3 Challenge

In Week 2 against the Seattle Seahawks, Brissett endured a rough outing, completing just 58% of his passes for 215 yards with one touchdown and two interceptions. The Cardinals fell short in a divisional battle, and Brissett shouldered much of the blame. However, as the Vulius NFL Analysis Desk notes, the veteran quarterback has a track record of resilience. He'll need to bounce back quickly because the 49ers' defense presents a formidable challenge. San Francisco boasts one of the league's most aggressive front sevens, led by Nick Bosa, and a secondary that thrives on turnovers.

Fantasy and Betting Implications

From a fantasy football perspective, Brissett remains a QB2 option at best. His ceiling is limited by Arizona's conservative offensive approach and a lack of elite weapons outside of Marquise Brown. However, his rushing upside—he's averaged 15 rushing yards per game this season—adds a slight boost in deeper leagues. For bettors, the Cardinals are currently 3.5-point home underdogs, per Vulius Sports' consensus odds. Brissett's health could shift that line slightly, but the 49ers remain heavy favorites.

What's Next for Arizona?

With Brissett healthy, the Cardinals can focus on game-planning for a 49ers team that has won three of the last four meetings. Head coach Jonathan Gannon emphasized the importance of starting fast and protecting the football. "We can't afford to give a team like San Francisco extra possessions," Gannon said earlier this week. "Jacoby knows that. He's been in this league long enough to understand what's at stake."

As the Vulius NFL Analysis Desk continues to monitor, Brissett's full participation is a promising sign for Arizona. But the true test comes Sunday when the lights brighten at State Farm Stadium. For die-hard Cardinals fans, all eyes will be on No. 12 to see if he can engineer an upset and silence the doubters.

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